We have been developing a method that does not target a specific gene or antigen but instead targets a key metabolic property of tumors – their preference for glycolytic metabolism (the Warburg effect). Targeted therapies are under development and show promising activity but are generally not curative since tumors exhibit a remarkable facility for circumventing these agents. There is currently no effective way to treat the disseminated disease. It can only be cured by surgical excision, but the tumor recurs in about 20% of the cases. Melanoma is the deadliest skin cancer and the most rapidly increasing malignancy among Caucasian populations throughout the world. Selective Acidification of Melanoma by inhibition of monocarboxylic acid transporters We are extending this approach to other signaling pathways such as ALK and PI3K/AKT inhibitors. We can readily detect this effect by monitoring lactic acid in the tumor (in both mice and men). We have recently demonstrated that administration of specific inhibitors of mTOR produces a marked reduction in glycolytic metabolism as a consequence of decreased expression of hexokinase-2 and other glycolytic enzymes. Detecting tumor response to inhibitors of signal transduction pathways is a major challenge in the clinic. We are also exploring the use of hyperpolarized 13C-labeled substrates to the study of tumors. By monitoring the kinetics of 13C-isotope exchange and fitting these data to a metabolic network model, we can quantitate flux through specific pathways of tumor energy and phospholipid metabolism and translate this into the amount of ATP that is produced from various substrates in tumors. We have recently discovered that NHL tumors in mice are quite unique in that they exhibit extremely well resolved 13C MR spectra. Our focus is largely on non-Hodgkin’s lymphoma (NHL) since this malignancy exhibits roughly a 50% response rate. My laboratory has been developing 31P, 1H and 13C MRS methods as well as physiologically sensitive MRI techniques for monitoring metabolic changes in tumors that predict or detect therapeutic response we generally develop these methods in perfused cells and mice and then translate them to human patients. In 2011 I shared the Gold Medal of the International Society of Magnetic Resonance in Medicine with John Griffiths of Cambridge University for our pioneer work on MRS of cancer. My laboratory initiated the field of NMR spectroscopy of tumors in mice in about 1980 by demonstrating that tumors exhibited detectable changes in bioenergetics, pH and phospholipid metabolism that could be utilized for detection and prediction of therapeutic response. Prediction and Early Detection of Response of non-Hodgkin’s Lymphoma
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The ability to order a ride from your phone, confirm the price ahead of time, and pay on your card (instead of worrying about getting cash from an ATM at the airport) is nothing short of a superpower. Here are the four biggest reasons why apps are almost always better than taxis when you travel: Here’s a full breakdown of the costs of using ridesharing apps like Uber and Lyft versus local taxis and the pros and cons-for you and the drivers-of each service when you travel. You need to know the best options, a few common scams and red flags to avoid, and (approximately) what a car or taxi should cost in most places around the world so you can get where you need to go. Plus, you can throw your backpack in the trunk of the taxi instead of trying to squeeze it onto the train. In fact, in some countries, a car is cheaper than getting a bus to the airport. If you’re traveling with a friend or partner, taking a car or taxi doesn’t cost much more than a bus or subway. The extra cost of taking a car or taxi is almost always worth it when you’re traveling, especially if your time is limited. Make sure that you crunch the numbers and use what’s best for you-and your driver-to get where you need to go safely and within your budget. Ridesharing apps like Uber, Lyft, and Grab have transformed the way we travel. Should You Use an Uber, Lyft, or Taxi When You Travel?.Public Transportation Alternatives While Traveling.How to Save Money on an Uber or Lyft While Traveling.Pros of Uber, Lyft, and Grab for Travel. Making brilliant use of your partner, Six, Little Nightmares 2 builds on the first game well, but mostly sticks to what it knows best to great effect. It hits on a lot of the same notes throughout-and often the same notes as the original-but it plays them so well that it never feels repetitive. It’s a game which pulls you into the shadows, knowing how to get scares without slapstick horror. Little Nightmares 2 gets most things right, from the unsettling atmosphere and brilliant character design to the fascinating puzzles, but the combat is a swing and a (very slow) miss. With some enemies swarming you or jumping at you rapidly, it's just too slow. That's because all the melee weapons you're provided with are too big for you, so you have to drag them across the floor, heave them up, then crash them down. Thankfully, it's used sparingly, but if you ever have to fight your way out of a situation, prepare to be endlessly frustrated. Are there any plans to add multiplayer or co-op mode There are currently no plans to add multiplayer features to. Unfortunately, whether it happens in big spaces or small spaces, the combat is pretty bad. Little Nightmares II is a single-player game. As a result, even the more elaborate ones never get too frustrating, because you always know the solution is here somewhere. This makes it much easier to explore every nook and cranny for that hidden key, that secret lever, that solution satanically scrawled on the wall in erratic chalk markings. While exploration makes the levels more expansive than they initially appear to be, the puzzles often happen in small, truncated spaces. The puzzles make the most of space too, though in a very different way. There are still limits to this-the camera remains fixed and eventually you'll hit an invisible wall-but it makes the levels feel more like actual places and not like simple A to B throughlines as some sections can feel like in other sidescrollers. Since it's a 2.5D affair, there are times when you can wander off into the background and explore, sometimes finding hidden collectibles or easter eggs nestled away. Little Nightmares 2 makes the most of open spaces. Six is basically there to help you complete puzzles, give you general hints when you’re stuck, and protecting her drives a lot of the narrative, loose though it may be. It offers very little instruction or handholding (apart from a literal handholding mechanic with your partner, Six), but that suits the eerie tones, and such trust in the player is welcome. It's tempting to keep focusing on the visuals, but the gameplay doesn't just exist to lead you from one scene to the next. The aesthetic plays a big part in elevating the game's inherent creepiness, building a foreboding sensation with each footstep. What do you think? Let us know in the comments below.While "it's a chase game" is a simplistic reduction of what Little Nightmares 2 is-and doing so ignores the great puzzle aspects of the game-it's definitely built around the notion of wringing every ounce of creativity possible out of relatively simple gameplay loops. It was just the wrong choice, It’s important that we have control over the tension and the tone… so we just knew that it was the right thing to go singleplayer. To that end, they decided to ditch multiplayer and focus on making Little Nightmares II a satisfying single player experience. Speaking to Gaming Boulevard, Tarsier explained that co-op was considered at one point during development, but the team found that it took too much away from the game’s intended atmosphere and tone. Thats right: Little Nightmares 2 will offer no multiplayer, so if you were hoping to get some frights in with a pal or a partner, tough luck. While many assumed that this meant the sequel would feature cooperative multiplayer, Tarsier Studios have since confirmed that the game is in fact single player only, with Six remaining AI-controlled throughout the experience. In the reveal trailer shared at Gamescom 2019, it was shown that the new protagonist Mono would be joined on his adventure by the original protagonist Six from the first Little Nightmares. Earlier this week, Tarsier Studios announced Little Nightmares II for release sometime in 2020. And it’s likely not a term that New Yorkers were familiar with. But if you are up front right away, they’ll listen.” Even though New Yorkers had experienced major flash flooding from Hurricane Henri less than two weeks earlier, Ida’s rainfall prompted the city’s first ever “flash flood emergency.” It’s a newer term, Lanza says, created by the National Weather Service in the past decade to go one step beyond a flash-flood warning and communicate urgency. “If you go too far, people will tune you out. “Are alerts going out on people’s cell phones? How do we communicate? And are we doing a good enough job? Because I’m not going to stand here and guarantee it won’t happen again tomorrow.”Ĭonveying the deadly risk of fast-rising waters is the biggest challenge with flash flooding, says Matt Lanza, a meteorologist and managing editor for Space City Weather in Houston, where in 2017 he had to convey the risks of an unfathomable flooding forecast during Hurricane Harvey that ended up becoming the most extreme rain event in U.S. “Is our communication system adequate to let people know in homes and on subways that this is dangerous?” she asked. The following morning, as dozens of people had been killed in flooded basement apartments and in cars on roadways, New York Governor Kathy Hochul specifically singled out emergency-alert systems when she asked what had failed. “Areas that don’t normally experience flash flooding, could.” But after the suddenness and severity of the storm and its flooding became clear, a lot of people began to question whether that information had made it into New Yorkers’ decision-making that night. “Widespread major flood impacts, especially in urban areas and areas of steep terrain,” it warned. “Significant and life-threatening flooding,” reported the National Weather Service’s New York office on the morning of September 1, as the still-churning remnants of Hurricane Ida headed northeast. It was, meteorologically speaking, a perfect forecast. Photo-Illustration: Curbed Photos: Tina Keon Getty Images New Yorkers were overwhelmed by information as Ida’s unprecedented rainfall flooded the city. The Noble Quran (Hilali–Khan), which is said to be the most widely disseminated Quran in most Islamic bookstores and Sunni mosques throughout the English-speaking world, defines the two groups as Jews and Christians respectively. : 45 Others view this as an exclusive condemnation of all Jews and Christians from all times. Some Muslim commentators believe Jews and Christians are examples of those evoking God's anger and those who went astray, respectively. The final three verses, which comprise the servant's half, begin with the servant stating that they worship and seek only God's help (verse 4/5), asking Him to guide them to the Sirat al-Mustaqim (the Straight Path) of those who God has been bountiful to, and not of those who have earned His anger (verses 5-6/6-7). The chapter begins by praising God with the phrase Alhamdulillah, and stating that it is God who has full authority over all creations (verse 1/2), that He is Ar-Rahman Ar-Rahim or the Most Gracious and Most Merciful (verse 2/3), and that He is and will be the true owner of everything and everyone on the Day of Judgement (verse 3/4). There is disagreement as to whether the Bismillah is the first verse of the surah, or even a verse in the first place. Surah Al-Fatiha is narrated in the Hadith to have been divided into two halves between God and His servant (the person reciting), the first three verses being His half and last three being the servant's. Some Muslims interpret it as a reference to an implied ability of the Surah to open a person to faith in God. The primary literal meaning of the expression "Al-Fatiha" is "The Opener/The Key", which could refer to this Surah being the first in the Quran, the first chapter recited in full in every rakat of salah, or to the manner in which it serves as an opening for many functions in everyday Islamic life. Quranic chapter titles are not considered by Muslims to be part of the divine revelation of the Quran. Al-Fatiha is recited in Muslim obligatory and voluntary prayers, known as salah. It consists of 7 ayah (verses) which are a prayer for guidance and mercy. 'The Opening' or 'The Opener'), is the first surah (chapter) of the Quran. Chester Beatty LibraryĪl-Fatiha (alternatively transliterated Al-Fātiḥa or Al-Fātiḥah Arabic: ألْفَاتِحَة, IPA: lit. Headings for Al-Fatiha, and for Chapter 2, Al-Baqara. 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Then, do not assume that only because we have a tar.gz, we can install its software. Many tar.gz files could be used for several other types of objectives like storing a group of documents. Various tar.gz files are the same as the ZIP files.Įssentially, not all the tar.gz files that we trigger on Ubuntu include an installable application. It means that this file includes single or multiple files in it which can be compressed into one archive file. Also, the word tarball is used for referring to the tar file.Ī file containing an extension, i.e., tar.gz can be described as an archive file. tar file suffix that is 2,, , or package.tar. The term tar is considered through (t)ape (ar)chive. Often, it is known as a tarball and used for backup and distribution objectives. Tar can be defined as a software utility in computing to collect several files into a single archive file. In this article, we will discuss how to install a tar.gz file on the latest Ubuntu versions. Thanks.If we are using Ubuntu Linux, we will later or sooner find ourselves faced with the operation in which we need to install a tar.gz file. If you liked this post about How to Install tar.gz in CentOS, please share it with your friends on social networks or simply leave a comment in the comments section. Our admins will Install tar.gz in CentOS for you immediately. Of course, if you are one of our CentOS Hosting customers, you don’t have to Install tar.gz in CentOS, simply ask our admins, sit back and relax. But right now, this is the “standard” way to install tar.gz files in Linux. Later on, you’ll see how to install packages so that you don’t have to rely on the good graces of the programmer for uninstallation. If the code is good however, you should be able to navigate to the installation folder as in Step 4 and type: sudo make uninstallĪnd this should remove the package from your system. If not, removing all the files that where installed can be a massive pain in the neck. Here you’ll have to hope and pray that the package developer has included an uninstall script. So let’s get started!Īs you can see, it works! We’ve successfully compiled and installed a Linux package! Step 7: Removing the Package If you don’t have a user capable of running sudo, then either you create one, or log in as root yourself. If you’re not logged in as root (and ideally you shouldn’t be!), then you’ll need to use the “sudo” command. The final process of installing these files requires root permissions. Permissions to Compile and Install tar.gz Files But for now, we’re going to assume that the package you want to install is well made and adheres to the important coding standards. Later on, we’ll show you a safe way to do this so that you can remove packages completely even without an uninstaller. There might not be a default way to remove the package and all its files. However, packages in the wild might not be well made. To uninstall a package, we just need to type: yum remove xyz One of the reasons why package managers like yum are so useful is that they take care of cleaning up after you’re done. In this article, we’ll show you how to install tar.gz files using the traditional manner on a fresh CentOS install. There’s a lot of it lying wild out there, just waiting to be compiled and installed. |
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